Clean, instant fuel for a sharper mind. Brain Ketone™ delivers 5 grams of patented goBHB® beta-hydroxybutyrate, the primary ketone your body makes, plus magnesium, potassium and sodium, for focused, crash-free mental energy. Power your brain. Elevate your day. Unlock your MOOD · MIND · MEMORY.*

Your brain is the most energy-hungry organ in your body, and it has a clear favorite fuel. Not sugar. Not caffeine. Ketones. Brain Ketone gives your brain clean, ready-to-use ketone fuel that goes straight to work, without the spikes, crashes and brain fog of conventional energy sources. One scoop. Zero guesswork. Pure cognitive horsepower.*

Why you'll love Brain Ketone

• Sharper focus and concentration*
• Faster recall and memory support*
• Sustained, crash-free mental energy*
• Elevated mood and mental clarity*
• Hydration and electrolyte balance with magnesium, potassium and sodium*
• Zero sugar, zero carbs, zero stimulants. Unflavored and instantly soluble.

Fuel your brain the way nature intended

Your brain makes up only about 2% of your body weight, yet it uses about 20% of your body's energy. Most of the time it runs on glucose. But when glucose is scarce, during fasting, exercise or a ketogenic diet, your liver produces ketones, and your brain readily switches over to this cleaner, more efficient fuel.*

• A premium fuel: Beta-hydroxybutyrate (BHB) produces more energy per unit of oxygen than glucose, helping your brain cells make energy more efficiently.*
• A powerful backup: During prolonged fasting, ketones can supply up to 60% of the brain's energy needs.

More than fuel: ketones are powerful messengers

For decades, ketones were thought of as simply a backup fuel. Science now tells a much bigger story. A 2025 review in Experimental Physiology from the University of Alberta describes ketones as powerful signaling molecules. Beyond supplying energy, BHB carries important messages to your brain, your body and the genes inside your cells.*

• Messages to your cells: BHB binds to specific receptors on the surface of cells, known as G-protein coupled receptors (including HCAR2, also called GPR109A), much like a key fitting a lock. This lets ketones send signals that influence metabolism, fat release and immune activity throughout the body.*
• Messages to your genes: BHB can change how your genes are expressed. It helps switch on protective genes through epigenetic mechanisms, including a newly discovered process called β-hydroxybutyrylation, in which BHB directly tags the proteins that package your DNA.*
• Messages to calm inflammation: BHB inhibits the NLRP3 inflammasome, one of the body's master switches for inflammation. Through the HCAR2 receptor, ketones also help shift immune cells, including those in the brain, toward a calmer, more protective state.*
• Brain-protective signals: BHB also supports healthy BDNF levels, a key protein for the growth and health of brain cells, and activates the body's own antioxidant defenses.*

Good for your whole body

• Heart: Your heart is the largest consumer of ketones in the body, and it readily burns them for clean, efficient energy (more below).*
• Muscles and recovery: Skeletal muscle is an avid user of ketones, especially during exercise. Ketones help spare glucose and muscle protein, and research shows they support recovery by favoring muscle protein building over breakdown.*
• Metabolic health: Healthy ketone metabolism supports balanced energy use across the brain, heart, muscles and liver.*

Every scoop of Brain Ketone delivers not just fuel, but a message: one that tells your brain and body to protect, repair and perform.*

Ketones for your heart, and the heart-brain connection

Your heart beats more than 100,000 times a day and never gets to rest. To keep up, it constantly draws on multiple fuels, and ketones are one of its most important. In fact, the heart is the largest consumer of ketones in the body.*

What the research shows

A 2025 study from Rutgers New Jersey Medical School, published in the Journal of the American Heart Association, found that the heart's ability to use ketones is essential for maintaining normal heart function during aging.

• Ketone use declines with age: The key enzyme the heart needs to break down and use ketones (called SCOT) decreases as the heart ages.
• Without ketones, the aging heart struggles: Mice whose hearts couldn't use ketones had normal heart function when young, but progressively developed weaker pumping and structural changes as they aged.
• Ketones came to the rescue: Supplying extra ketones partially restored the heart's pumping strength in these mice.
• More than fuel, again: The heart benefited from ketones even when it couldn't burn them for energy, showing that ketones protect the heart through their signaling actions as well. This matches the "powerful messenger" role described above.

A healthy heart feeds a healthy brain

Your brain depends on your heart and circulatory system for every breath of oxygen and every bit of fuel it uses. Although it makes up only about 2% of your body weight, your brain receives roughly 15% of the blood your heart pumps with every beat, delivered through a vast network of arteries and tiny capillaries. When the heart pumps strongly and blood vessels stay healthy, the brain gets a steady supply of oxygen and nutrients. When circulation falters, the brain is among the first organs to feel it.*

That's why brain health and heart health are inseparable. By supplying clean ketone fuel to both the heart and the brain, Brain Ketone supports the whole system: a strong, efficient heart that keeps blood flowing, and well-fueled brain cells at the other end of the line. For complete circulatory support, pair it with Brain Cardio.*

Why ketones? Why now?

As we age, navigate chronic stress and lose metabolic flexibility, the brain's ability to efficiently use glucose begins to falter. The result can be mental fatigue, slower recall, foggy thinking and difficulty focusing on the things that matter most.

• The energy gap: Brain imaging research shows that the brain's uptake of glucose declines with age, which can leave brain cells short on energy.
• Ketones still get through: The same research shows the aging brain's ability to take up and use ketones remains intact. Ketones offer a way to help close the energy gap.*
• No strict diet required: Getting into ketosis through diet alone can take days of strict carb restriction. Brain Ketone delivers ketones directly, raising blood BHB levels within about 30 to 60 minutes, no fasting or keto diet needed.*

Brain Ketone was formulated to help restore the metabolic efficiency your brain craves.*

The midlife "critical window" for your brain

A landmark 2025 study published in the Proceedings of the National Academy of Sciences (PNAS) analyzed brain scans from more than 19,300 people and found that brain aging doesn't happen in a straight line. It follows a predictable curve with clear turning points:

• Around age 44: Brain networks begin to destabilize, the first measurable stage of brain aging.
• Around age 67: Destabilization reaches its fastest pace.
• The driver: The researchers linked these changes most strongly to rising insulin resistance and poorer blood sugar control, not to blood pressure or inflammation. As neurons become insulin resistant, they struggle to take in glucose, their main fuel, and begin running short on energy.
• Ketones bypass the problem: Neurons take up ketones through a different doorway, the MCT2 transporter, which doesn't depend on insulin. Brain areas rich in this ketone transporter were more resilient to aging.
• Ketones restabilized the brain: In the study's intervention arm, 101 adults ages 20 to 79 received a single drink of D-BHB ketones or a calorie-matched glucose drink. Ketones produced robust, significant restabilization of brain networks, and the benefit was strongest in adults ages 40 to 59. The same number of calories from glucose had no significant effect.

The researchers describe midlife as a "critical window," a period when brain cells are under metabolic stress but still able to respond to a better fuel. In their words, the brain's energy systems "bend" before they "break." Supporting your brain with ketones in your 40s and 50s may be one of the smartest investments you can make in your long-term brain health.*

What the research shows: ketones and cognition

The evidence is clear and growing: giving the brain ketones helps it perform.*

• A 2026 meta-analysis: A systematic review and meta-analysis published in Frontiers in Nutrition reviewed 38 randomized controlled studies with more than 1,600 participants. Pooling the data from over 1,100 of them, the researchers found that exogenous ketones, like the BHB in Brain Ketone, significantly improved cognitive performance compared with placebo, in healthy adults and clinical populations alike.
• Consistent benefits across the board: The cognitive benefits held up with a single serving or with daily use over weeks, in healthy adults and in people with memory concerns, and whether or not people were under mental stress.
• Ketones without the diet: The researchers note that exogenous ketones raise blood ketone levels quickly and in a dose-dependent way, even when eaten alongside carbohydrates, with no currently known safety concerns.
• Ketone minerals and mood: In a 6-week, double-blind study from The Ohio State University published in Frontiers in Neuroscience, adults following a ketogenic weight-loss diet took BHB bound to minerals, the same type of ketone used in Brain Ketone, or a placebo twice daily. At week 2, the placebo group had higher depression scores and lower scores on a math processing test than the ketone group. The researchers concluded that the ketone supplement may help ease the negative mood that can come with the early "keto-adaptation" phase.

Ketones and migraines: what the research shows

For many people, migraines aren't just headaches. They're days lost to pain, light sensitivity and brain fog. A growing body of research is looking at an unexpected piece of the puzzle: brain energy. Scientists are investigating whether ketones, the brain's alternative fuel, could play a role.

The energy connection

Research suggests the migraine brain may be running on an energy deficit. Studies have linked migraine to reduced brain energy reserves, impaired glucose transport into the brain and increased oxidative stress. When the brain's energy supply can't keep up with demand, it may become more vulnerable to the chain of events behind a migraine attack.

How ketones may help

A 2019 review in Nutrients outlined several ways ketone bodies such as beta-hydroxybutyrate (BHB) may support the migraine-prone brain:

• An alternative fuel: Ketones give brain cells an efficient energy source that doesn't depend on glucose transport, helping bypass the energy shortfall.
• Calming inflammation: BHB helps suppress the NLRP3 inflammasome, a key inflammatory switch, and lowers oxidative stress.
• Steadying overexcited nerve cells: Ketones help support GABA, the brain's calming neurotransmitter, and help stabilize the ion channels that control how easily brain cells fire.

What the studies show

• Ketosis and migraine frequency: A 2023 systematic review and meta-analysis in Frontiers in Nutrition found that ketosis, mostly through ketogenic and modified Atkins diets, was associated with a significant reduction in monthly migraine attacks.
• A promising pilot: A small pilot study of BHB ketone supplementation reported that average migraine days were cut by about half, from 16 to 8 per month.
• The first controlled trial and a "metabolic migraine" subgroup: In a 2022 double-blind, placebo-controlled crossover trial of 41 people with episodic migraine, BHB didn't significantly reduce migraine days for the group as a whole. But a follow-up analysis found a distinct subgroup, people with a "metabolic migraine" profile identified by blood markers, who responded strongly. They had 5.7 fewer migraine days than on placebo. The researchers concluded that ketones may be most helpful for people whose migraines are linked to metabolic and energy imbalances.

The science is still young. Most of the evidence so far comes from ketogenic diets, the studies are small, and larger trials are needed. But the energy, inflammation and nerve-stability pathways ketones influence are exactly the ones researchers link to migraine, which makes this one of the most interesting areas in brain-energy research today.

Brain Ketone delivers goBHB®, the same type of ketone studied in this research, to support healthy brain energy, a balanced inflammatory response and a calm, focused mind.* If you experience migraines, talk with your healthcare provider about whether ketones are right for you.

goBHB®: a patented, premium ketone

Brain Ketone is made with goBHB®, a patented form of beta-hydroxybutyrate bound to three essential minerals: magnesium, potassium and sodium. This 3-in-1 ketone mineral blend delivers a full 5 grams of BHB per scoop, and the minerals do double duty as electrolytes.*

• Magnesium (200 mg, 47% DV): Supports energy production, nerve and muscle function, and a calm, focused mind. Most people don't get enough.*
• Potassium (796 mg, 17% DV): Supports healthy fluid balance, nerve signaling and muscle function.*
• Sodium (250 mg, 10% DV): A moderate amount to help maintain hydration, especially during exercise, fasting or a low-carb diet.*

When you cut carbs, fast or train hard, your body loses electrolytes more quickly, which can contribute to the fatigue, brain fog and low mood some people feel in the first weeks of a low-carb diet. Brain Ketone helps replace those minerals while it fuels your brain.*

A note from our formulator

"I formulated Brain Ketone to give the brain exactly what it runs best on: clean, bioidentical ketones with the electrolytes your body needs to keep up. One scoop, real cognitive lift."
— Dr. Michael Nelson, Formulator

Built for real life: mix it into anything

Because Brain Ketone is completely unflavored and dissolves instantly, it's one of the most versatile ketone supplements you'll ever own. Stir it into:

• Your morning water
• Brain Bean Coffee or Zen-Blend Coffee, for an unstoppable cognitive stack
• A spoonful of Ultra C8 MCT Oil, for a double dose of ketone power
• A post-workout protein shake
• Your favorite smoothie or pre-workout
• Anything, anytime you need a clean, instant lift

Stack it. Amplify it. Master your mind.

Brain Ketone is exceptional on its own and extraordinary when paired with the rest of the Brain Bean family:

• Brain Bean Coffee: for elevated daily energy and clarity
• Brain Bean Zen-Blend Coffee: organic coffee infused with Sensoril® ashwagandha, Alpha-GPC, L-theanine and C8 MCT oil, for calm, focused energy that pairs perfectly with ketones
• Ultra C8 MCT Oil: for even more ketone production. Brain Ketone delivers ready-made BHB that goes to work right away, while C8 MCT oil is rapidly converted by your liver into your own ketones. Together they give you an immediate lift plus a longer-lasting supply of ketone fuel.*
• Micronized Creatine Monohydrate: for cellular and cognitive resilience
• Brain Cardio: for full-spectrum circulatory and brain support

Together, they form a complete cognitive performance system, engineered for people who refuse to settle for average mental output.

What's inside (per scoop)

• Beta-hydroxybutyrate (as goBHB®), 5,000 mg
• 3-in-1 Ketone Mineral Blend (goBHB® magnesium, goBHB® sodium, goBHB® potassium), 6,450 mg, providing:
  • Magnesium, 200 mg (47% DV)
  • Potassium, 796 mg (17% DV)
  • Sodium, 250 mg (10% DV)

Other ingredients: silicon dioxide. Zero sugar. Zero carbs. Zero stimulants.

How to use

Mix 1 scoop (about 6.5 g) into 8–12 oz of water, coffee, a shake or a smoothie. Use once a day, twice a day, or whenever you need to elevate your edge. Each container provides 60 servings.

Storage tip: Brain Ketone is naturally hygroscopic, meaning its minerals readily draw in moisture from the air. If the container is left open or stored in a humid spot, some clumping can occur, especially after the first week or so of opening. This is completely normal and does not affect the product's effectiveness. Simply break up any clumps with your scoop or a spoon and use as directed. To minimize clumping, close the lid tightly after each use and store in a cool, dry place.

Quality you can trust

• Physician formulated
• Made in the USA in an FDA-registered, cGMP-certified facility
• Third-party tested for purity and potency
• Unflavored, sugar free, carb free and stimulant free

Frequently asked questions

Do I need to be on a keto diet?
No. Brain Ketone delivers ketones directly, so you can enjoy the benefits of ketone fuel without fasting or following a strict ketogenic diet. If you are on a keto or low-carb diet, it's a great way to support your ketone levels and electrolytes.*

Will it kick me out of ketosis?
No. Brain Ketone contains zero sugar and zero carbs.

How fast will I feel it?
BHB is absorbed quickly, and blood ketone levels typically rise within about 30 to 60 minutes.*

Does it contain caffeine?
No. Brain Ketone is stimulant free. For an extra lift, stir it into your Brain Bean Coffee.

What does it taste like?
It's unflavored and dissolves instantly, so it blends easily into water, coffee, shakes and smoothies.

Why is my Brain Ketone clumping?
The mineral-bound ketones in Brain Ketone are very hygroscopic, which means they naturally attract moisture from the air. Once the container has been open for a week or more, some clumping is normal. It does not affect the product's effectiveness in any way. It's simply the nature of the product. Just break up the clumps and use as directed, and keep the lid tightly closed between uses.

The bottom line

If you're ready to think more clearly, remember more sharply, focus more deeply and feel more like you, every single day, Brain Ketone is your daily cognitive upgrade. One scoop. Five grams of BHB. Clean, crash-free mental energy. Watch your MOOD · MIND · MEMORY soar to new levels.*

Scientific references

1. Antal BB, et al. Brain aging shows nonlinear transitions, suggesting a midlife "critical window" for metabolic intervention. Proceedings of the National Academy of Sciences (PNAS). 2025. doi.org/10.1073/pnas.2416433122
2. Bonnechère B, et al. The effect of exogenous ketone bodies on cognition across health and disease: a systematic review and meta-analysis. Frontiers in Nutrition. 2026;13:1802531. doi.org/10.3389/fnut.2026.1802531
3. Kackley ML, et al. The effects of a 6-week controlled, hypocaloric ketogenic diet, with and without exogenous ketone salts, on cognitive performance and mood states in overweight and obese adults. Frontiers in Neuroscience. 2022;16:971144. doi.org/10.3389/fnins.2022.971144
4. Tabatabaei Dakhili SA, et al. The multifaceted roles of ketones in physiology. Experimental Physiology. 2025. doi.org/10.1113/EP092243
5. Keller MA, Nakamura M. Ketone catabolism is essential for maintaining normal heart function during aging. Journal of the American Heart Association. 2025;14:e042508. doi.org/10.1161/JAHA.125.042508
6. Cunnane SC, et al. Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing. Nature Reviews Drug Discovery. 2020;19:609–633. doi.org/10.1038/s41573-020-0072-x
7. Owen OE, et al. Brain metabolism during fasting. Journal of Clinical Investigation. 1967;46(10):1589–1595. doi.org/10.1172/JCI105650
8. Veech RL. The therapeutic implications of ketone bodies. Prostaglandins, Leukotrienes and Essential Fatty Acids. 2004;70(3):309–319. doi.org/10.1016/j.plefa.2003.09.007
9. Youm YH, et al. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nature Medicine. 2015;21(3):263–269. doi.org/10.1038/nm.3804
10. Shimazu T, et al. Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science. 2013;339(6116):211–214. doi.org/10.1126/science.1227166
11. Gross EC, Klement RJ, Schoenen J, et al. Potential protective mechanisms of ketone bodies in migraine prevention. Nutrients. 2019;11(4):811. doi.org/10.3390/nu11040811
12. Neri LCL, Guglielmetti M, Fiorini S, et al. Ketosis and migraine: a systematic review of the literature and meta-analysis. Frontiers in Nutrition. 2023;10:1204700. doi.org/10.3389/fnut.2023.1204700
13. Metagenics Institute. A novel therapeutic approach for migraines: ketone supplementation. metagenicsinstitute.com
14. Putananickal N, Gross EC, Orsini AL, et al. Efficacy and safety of exogenous beta-hydroxybutyrate for preventive treatment in episodic migraine: a single-centred, randomised, placebo-controlled, double-blind crossover trial. Cephalalgia. 2022;42:302–311. doi.org/10.1177/03331024211043792
15. Gross EC, Putananickal N, Orsini AL, et al. Defining metabolic migraine with a distinct subgroup of patients with suboptimal inflammatory and metabolic markers. Scientific Reports. 2023;13:3787. doi.org/10.1038/s41598-023-28499-y

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.