Support healthy circulation to your heart and brain with 5,000 FU of high-potency nattokinase, for your MOOD · MIND · MEMORY.

Your brain is only about 2% of your body weight, yet it receives roughly 15 to 20% of your blood flow. Every thought depends on a steady supply of oxygen and nutrients delivered through healthy blood vessels. Nattokinase is a natural enzyme discovered in natto, a traditional Japanese food made from fermented soybeans that has been enjoyed for over a thousand years. Researchers first identified the enzyme in the 1980s, and it has been studied ever since for its role in healthy circulation. Brain Basics Ultra-Pure Nattokinase delivers a high-potency 5,000 FU in every serving, for a research-level 10,000 FU a day.

Why you'll love Ultra-Pure Nattokinase

• Supports healthy circulation throughout the body, including blood flow to the brain
• Supports healthy blood flow by helping the body break down fibrin, a protein involved in normal clotting
• Supports heart health and healthy blood pressure levels already within the normal range
• Supports balanced fibrin levels, which naturally tend to rise with age
• High potency: 5,000 FU per serving and 10,000 FU a day, about five times the typical 2,000 FU dose
• Research-level dosing in the same daily range used in clinical studies
• Dairy-free and gluten-free

Circulation: the lifeline of a healthy brain

Healthy blood flow is one of the most important foundations of brain health. Your brain cells can't store energy, so they depend on a constant, second-by-second supply of oxygen and glucose delivered by your circulation. Over time, factors like aging, inflammation and a less active lifestyle can make blood thicker and flow less freely. Supporting healthy circulation is a simple, powerful way to support clear thinking, steady energy and long-term brain vitality.

How nattokinase works

• Supports the breakdown of fibrin: Fibrin is a protein your body uses to form clots when needed. Nattokinase supports the body's natural process of clearing excess fibrin, helping maintain smooth, healthy blood flow.
• Supports healthy blood viscosity: By supporting balanced fibrin levels, nattokinase helps keep blood flowing freely through large and small vessels, including the tiny vessels that feed the brain.
• Supports healthy microcirculation: Your body's tiniest blood vessels, the capillaries, deliver oxygen and nutrients directly to your tissues, including the brain. Nattokinase supports the body's natural ability to clear fibrin from these small vessels, helping maintain healthy oxygen delivery and microcirculation.
• Supports healthy blood pressure: Research suggests nattokinase supports healthy blood pressure levels already within the normal range.

Nattokinase and the brain: new clinical research

Nattokinase's benefits for circulation are now being studied directly in the brain. In a six-month randomized, double-blind, placebo-controlled clinical trial published in 2025, adults with an average age of 58 took 8,000 FU of nattokinase daily. Compared with placebo, the nattokinase group showed a statistically significant improvement in visuospatial function, the brain's ability to judge shapes, distance and space, and a lower risk of decline in that area. Researchers also observed a trend toward better sleep quality. The authors described the findings as a promising early sign of nattokinase's potential to support brain health and called for longer studies.

That trial used 8,000 FU a day, well above the typical 2,000 FU supplement, which is one more reason we recommend 10,000 FU daily.

Dose matters: why we recommend 10,000 FU a day

When it comes to nattokinase, the number that counts is FU (fibrinolytic units), a measure of the enzyme's actual activity, not its weight in milligrams. And research shows the amount you take makes a real difference.

• The typical dose falls short: Most nattokinase supplements provide just 2,000 FU a day, often for cost reasons. Studies suggest that amount can support healthy blood pressure and basic circulation, but it may not be enough for broader cardiovascular benefits.
• What the research used: In a large, 12-month clinical study of more than 1,000 adults, a daily intake of 10,800 FU was associated with significant improvements in total cholesterol, LDL cholesterol, triglycerides and markers of arterial health, and it was well tolerated. Lower daily amounts of 3,600 FU or less did not produce the same results.
• Why more enzyme matters: Supporting the breakdown of fibrin, healthy blood viscosity and healthy arteries is dose-dependent. It takes a meaningful, consistent level of active enzyme in the bloodstream over time.

Why twice a day? To be effective, an oral enzyme has to survive digestion, pass through the gut wall and reach the bloodstream in meaningful amounts. That is why research and practitioner protocols commonly split nattokinase into two daily doses taken on an empty stomach, to keep active enzyme levels steady throughout the day.

That is why we formulated Ultra-Pure Nattokinase at a high-potency 5,000 FU per serving and recommend two servings a day. At 10,000 FU daily, you get roughly five times the typical 2,000 FU dose and the same range used in the research, with just four capsules a day.

What's inside (per 2-capsule serving)

• Nattokinase, 250 mg, providing 5,000 FU (enzyme activity in fibrinolytic units)

Other ingredients: vegetable capsule, vegetable stearic acid.

How to use

Take 2 capsules (5,000 FU) twice daily, for a total of 10,000 FU per day, or as directed by your healthcare practitioner. For best results, take on an empty stomach, 30 to 60 minutes before a meal or two hours after, to help protect the enzyme from stomach acid. Each bottle contains 120 capsules, a 30-day supply at the recommended amount.

Quality you can trust

Ultra-Pure Nattokinase is made in the USA in a GMP-certified, FDA-registered facility and is lab-tested for purity and potency.

Frequently asked questions

What is nattokinase?
Nattokinase is an enzyme produced when soybeans are fermented with the beneficial bacterium Bacillus subtilis natto to make natto, a traditional Japanese food. It is prized for its role in supporting healthy circulation.

What does "FU" mean?
FU stands for fibrinolytic units, a measure of how active the enzyme is. It is the most meaningful way to compare nattokinase products.

Can I take it with other Brain Bean products?
Yes. Ultra-Pure Nattokinase pairs well with Brain Omega™ and Brain Cardio for comprehensive heart and brain support. As with any new supplement, consult your healthcare professional before adding it to your routine.

Scientific references

1. Sumi H, Hamada H, Tsushima H, et al. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet. Experientia. 1987;43(10):1110-1111. doi.org/10.1007/bf01956052
2. Kim JY, Gum SN, Paik JK, et al. Effects of Nattokinase on Blood Pressure: A Randomized, Controlled Trial. Hypertension Research. 2008;31(8):1583-1588. doi.org/10.1291/hypres.31.1583
3. Chen H, Chen J, Zhang F, et al. Effective management of atherosclerosis progress and hyperlipidemia with nattokinase: A clinical study with 1,062 participants. Frontiers in Cardiovascular Medicine. 2022;9:964977. doi.org/10.3389/fcvm.2022.964977
4. Zhang K, Zhang X, Wang A, et al. Nattokinase supplementation for cognitive enhancement in asymptomatic intracranial/carotid stenosis: A randomized controlled trial. Journal of Stroke and Cerebrovascular Diseases. 2026;35(1):108511. doi.org/10.1016/j.jstrokecerebrovasdis.2025.108511

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.