Recharge your brain from the inside out. Brain ResQ™ is a physician-formulated mitochondrial formula that brings together five research-backed nutrients to help your cells make energy, renew their power plants and protect them from wear and tear, for a sharper brain and a healthier heart. MOOD · MIND · MEMORY.

Every thought, memory and heartbeat is powered by your mitochondria, the tiny power plants inside your cells. As we age, mitochondria become fewer, slower and more vulnerable to oxidative stress, and the organs that need the most energy, your brain and heart, feel it first. Brain ResQ combines PQQ, CoQ10, MenaQ7® vitamin K2, trans-resveratrol and quercetin in one daily capsule to support every stage of mitochondrial health: building new mitochondria, keeping them running efficiently and protecting them.*

Your brain is only about 2% of your body weight, yet it consumes 20% or more of all the energy your body produces. Your mitochondria are at the center of it all, generating the energy behind every thought, memory and mood. Supporting and optimizing your mitochondria is essential for a healthy brain, sharp cognition, resilience and lasting vitality.*

Why you'll love Brain ResQ

• Supports mitochondrial biogenesis, the growth of new mitochondria, with PQQ, resveratrol and quercetin*
• Supports cellular energy production with CoQ10, the spark plug of your mitochondria*
• Supports memory, focus and healthy brain aging*
• Supports heart and arterial health with MenaQ7® PharmaPure vitamin K2*
• Powerful antioxidant protection and a healthy inflammatory response*
• Physician-formulated 90-Day Mitochondrial Protocol to rebuild your cellular energy from the inside out*

Your brain runs on mitochondria

Your brain makes up only about 2% of your body weight, but it consumes 20% or more of all your body's energy, more than any other organ for its size. Your mitochondria are at the center of this. Each brain cell is packed with them, working around the clock to produce ATP, the energy currency of every cell, to power learning, memory, focus and mood. When your mitochondria thrive, your brain thrives. That's why supporting and optimizing your mitochondria is essential for a healthy brain, cognition, resilience and vitality. Your heart is just as demanding, beating more than 100,000 times a day.*

• Energy declines with age: Mitochondrial number and efficiency naturally fall as we get older, which can show up as mental fatigue, slower thinking and less stamina.*
• More wear and tear: Aging mitochondria leak more free radicals, creating oxidative stress that can damage the cell and the mitochondria themselves.
• A vicious cycle: Damaged mitochondria make less energy and more free radicals. Supporting mitochondrial renewal and protection helps break that cycle.*

The three Rs of mitochondrial health

• Renew: PQQ, trans-resveratrol and quercetin help activate PGC-1α, the master switch for mitochondrial biogenesis, so your cells can build new, healthy mitochondria. Resveratrol also supports mitophagy, the recycling of worn-out mitochondria.*
• Recharge: CoQ10 and vitamin K2 help keep the mitochondrial energy assembly line moving, so your cells produce energy efficiently.*
• Rescue and protect: Powerful antioxidants from all five ingredients help defend mitochondria against oxidative stress and support a healthy inflammatory response.*

Meet the ingredients: the science behind each one

Managing and supporting your mitochondria is at the center of a healthy brain. That's why every ingredient in Brain ResQ was chosen to support a different part of mitochondrial health, and each one is backed by human research.*

PQQ: build new mitochondria

What it does: Pyrroloquinoline quinone (PQQ) is a unique nutrient your body cannot make on its own. It activates PGC-1α, the master switch that tells your cells to build brand-new mitochondria, a process called mitochondrial biogenesis. PQQ is also an exceptionally durable antioxidant that can neutralize free radicals thousands of times over.*

What human research shows:

• Randomized, double-blind, placebo-controlled trials found that 20 mg of PQQ daily for 8 to 12 weeks improved executive function, cognitive flexibility and processing speed in both younger and older adults. The Brain ResQ 90-Day Protocol provides 60 mg of PQQ daily over 12 weeks.
• A 2024 human study of a PQQ combination found increased oxygen saturation in the prefrontal cortex, the brain's planning and focus center, along with higher levels of BDNF (brain-derived neurotrophic factor), a key protein for the growth and health of brain cells.

CoQ10: the spark plug of your cells

What it does: Coenzyme Q10 is an electron carrier in the mitochondrial energy chain, shuttling electrons so your mitochondria can efficiently produce ATP, your cells' energy currency. It's also one of the body's most important fat-soluble antioxidants, protecting cell membranes and mitochondria.*

What human research shows:

• Oral CoQ10 substantially raises CoQ10 levels in the blood.
• Human trials show CoQ10 supports healthy vascular function and can increase blood flow to the brain in older adults, helping deliver the oxygen and fuel brain mitochondria need.
• Natural CoQ10 production declines with age, and cholesterol-lowering statins can lower it further because they block the same pathway your body uses to make CoQ10. Your heart and brain, with their high energy needs, rely especially on adequate CoQ10.*

Quercetin: protect and partner

What it does: Quercetin is a natural flavonoid found in apples, onions and berries. It acts as an antioxidant that helps stabilize cell membranes and supports mitochondrial energy production. It also works alongside resveratrol to support mitochondrial biogenesis and helps enhance resveratrol's bioavailability, so you get more from every capsule.*

What human research shows:

• In a 2024 double-blind, randomized controlled trial, 92 adults with mild cognitive impairment took a highly bioavailable form of quercetin daily. After six months, the quercetin group showed a statistically significant improvement in cognitive scores (MoCA) and an increase in neuroprotective BDNF compared with placebo.
• These improvements tracked with lower levels of inflammatory messengers such as TNF-α, helping protect mitochondria from inflammation-driven damage.*

Trans-resveratrol: recycle, renew and restore blood flow

What it does: Trans-resveratrol, the active form of the polyphenol found in red grapes, activates SIRT1 and PGC-1α, the "longevity" pathways that trigger mitophagy, your body's system for clearing out and recycling damaged mitochondria so healthy new ones can take their place. Brain ResQ provides 250 mg of trans-resveratrol from Japanese knotweed root.*

What human research shows:

• Human clinical trials show trans-resveratrol reliably improves cerebrovascular responsiveness, the ability of the brain's blood vessels to dilate and deliver oxygen on demand.
• In long-term trials in postmenopausal women and older adults, daily doses of 150 to 500 mg improved verbal memory and psychomotor speed. Each Brain ResQ capsule provides 250 mg, right in that clinically studied range, and the 90-Day Protocol provides 1,000 mg daily.
• Researchers attribute these benefits to enhanced blood flow, which feeds your brain's mitochondria the glucose and oxygen they need to produce energy.*

MenaQ7® PharmaPure vitamin K2: keep the highways clear

What it does: MenaQ7® is a clinically studied, patented form of natural vitamin K2 as MK-7, the long-lasting form of K2 that stays active in the body for days. It activates matrix Gla protein (MGP), which helps keep calcium out of your arteries and soft tissues, and osteocalcin, which helps direct calcium into your bones. Vitamin K2 is often paired with resveratrol for complementary vascular and cellular benefits.*

What human research shows:

• Large human studies link higher K2 intake with less arterial calcification, supporting flexible, clear "vascular highways" that deliver blood and oxygen to your brain and heart.
• In the brain, vitamin K2 helps produce sphingolipids, a crucial class of fats in brain cell membranes and the myelin sheaths that insulate nerve fibers. By supporting the structure of brain cells, K2 helps preserve the environment your mitochondria need to work.
• Most Western diets are low in K2, which is found mainly in fermented foods like natto and certain aged cheeses.*

Better together

Each of these nutrients supports a different step in the mitochondrial life cycle: PQQ builds new mitochondria, CoQ10 powers them, quercetin protects them, resveratrol recycles the worn-out ones and restores blood flow, and K2 keeps the vascular highways clear. Many of these compounds are broken down quickly in the body when taken alone, which is why Brain ResQ pairs them strategically, such as quercetin to help boost resveratrol's bioavailability, for a formula where the whole is greater than the sum of its parts.*

Brain and heart, powered together

Your brain and heart are the two most energy-hungry organs in your body, and they depend on each other. A healthy heart and flexible arteries deliver the oxygen and nutrients your brain needs, and well-powered brain cells keep you sharp, focused and resilient. Brain ResQ supports both, at the level where it all begins: your mitochondria.*

What's inside (per capsule)

• Vitamin K2 (as MenaQ7® PharmaPure MK-7), 100 mcg (83% DV): supports healthy arteries, bones and mitochondrial energy
• Trans-resveratrol (from Japanese knotweed root extract), 250 mg: activates SIRT1 longevity pathways and supports healthy brain blood flow
• Quercetin (as quercetin anhydrous), 100 mg: supports mitochondrial biogenesis and resveratrol bioavailability
• Coenzyme Q10 (ubiquinone), 100 mg: powers mitochondrial energy production and antioxidant protection
• PQQ (pyrroloquinoline quinone disodium salt), 15 mg: supports the growth of new mitochondria

Other ingredients: vegetable capsule, microcrystalline cellulose.

How to use

The Brain ResQ 90-Day Mitochondrial Protocol

Take 2 capsules of Brain ResQ twice per day for 90 days.

Building new mitochondria and clearing out worn-out ones takes time. Our 90-day protocol is designed to give your cells a sustained, high-level supply of all five nutrients through the full cycle of mitochondrial renewal, so your brain and body can rebuild their energy capacity from the inside out.*

Your protocol dosing:

• AM: Take 2 capsules in the morning to power your day.
• PM: Take 2 capsules in the afternoon or evening to keep levels steady and support overnight cellular repair and renewal.*

• Why twice a day: Splitting your intake into two doses helps keep nutrient levels steady throughout the day and night, instead of one peak and a long dip.*
• What you'll need: The full 90-day protocol uses 360 capsules, or 6 bottles of 60 capsules.

Daily support

For everyday mitochondrial support, take 1 capsule daily, or as directed by your healthcare practitioner. Each bottle contains 60 capsules.

Quality you can trust

• Physician formulated
• Made in the USA in an FDA-registered, GMP-certified facility
• Third-party lab tested for purity and potency
• Soy free, dairy free and gluten free

Frequently asked questions

Why a 90-day protocol?
Mitochondrial renewal is a gradual process. Your cells need a steady, high-level supply of nutrients over weeks to build new mitochondria and recycle damaged ones. Many of the human studies on these ingredients ran for 8 weeks to 6 months, so 90 days gives your mitochondria the time they need to respond.*

What is mitochondrial biogenesis?
It's the process of building new mitochondria inside your cells. More healthy mitochondria means more capacity to produce energy. PQQ, resveratrol and quercetin all support this process.*

Why is vitamin K2 in a mitochondrial formula?
K2 supports your energy system in two ways. It helps keep arteries flexible and calcium where it belongs, supporting healthy blood flow to your brain and heart, and early research suggests it also supports mitochondrial energy production directly.*

I take a statin. Is CoQ10 important for me?
Statins work by blocking the same pathway your body uses to make CoQ10, so they can lower CoQ10 levels. Many people who take statins choose to supplement with CoQ10. Talk with your doctor about what's right for you.

Can I take Brain ResQ if I take a blood thinner?
Vitamin K can affect how some blood thinners, such as warfarin, work. If you take a blood thinner, talk with your doctor before using Brain ResQ.

Can I take it with other Brain Bean formulas?
Yes. Brain ResQ pairs well with Brain Omega, Brain Ketone and Opti D3 Plus for complete brain and heart support.

Scientific references

1. Raichle ME, Gusnard DA. Appraising the brain's energy budget. Proceedings of the National Academy of Sciences. 2002;99(16):10237-10239. doi.org/10.1073/pnas.172399499
2. Ulpathakumbura S, Lu SK, Gunarathne R, et al. Comparison of anti-aging effect of PQQ (Pyrroloquinoline quinone) and NMN/NR (Nicotinamide mononucleotide /Nicotinamide riboside) – possible combination use. Ageing Research Reviews. 2026;114:102992. doi.org/10.1016/j.arr.2025.102992
3. Baltic S, Nedeljkovic D, Todorovic N, et al. The impact of six-week dihydrogen-pyrroloquinoline quinone supplementation on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals with mild cognitive impairment: a randomized controlled trial. The Journal of nutrition, health and aging. 2024;28(8):100287. doi.org/10.1016/j.jnha.2024.100287
4. Nankivell MC, Rosenfeldt F, Pipingas A, et al. Coenzyme Q10 and Cognition: A Review. Nutrients. 2025;17(17):2896. doi.org/10.3390/nu17172896
5. Quercetin and cognition in mild cognitive impairment (IntechOpen chapter). www.intechopen.com/chapters/1237348
6. Tu W, Song M, Fan X. Does resveratrol improve cognition in humans? A scientometric study to an in‐depth review. CNS Neuroscience & Therapeutics. 2023;29(9):2413-2429. doi.org/10.1111/cns.14276
7. Boondam Y, Saefoong C, Niltup N, et al. The Cognitive Restoration Effects of Resveratrol: Insight Molecular through Behavioral Studies in Various Cognitive Impairment Models. ACS Pharmacology & Translational Science. 2024;7(11):3334-3357. doi.org/10.1021/acsptsci.4c00373
8. Kennedy DO, Wightman EL, Reay JL, et al. Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation. The American Journal of Clinical Nutrition. 2010;91(6):1590-1597. doi.org/10.3945/ajcn.2009.28641
9. Geleijnse JM, Vermeer C, Grobbee DE, et al. Dietary Intake of Menaquinone Is Associated with a Reduced Risk of Coronary Heart Disease: The Rotterdam Study. The Journal of Nutrition. 2004;134(11):3100-3105. doi.org/10.1093/jn/134.11.3100
10. Vos M, Esposito G, Edirisinghe JN, et al. Vitamin K 2 Is a Mitochondrial Electron Carrier That Rescues Pink1 Deficiency. Science. 2012;336(6086):1306-1310. doi.org/10.1126/science.1218632

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.